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Tager JM, Wanders RJ, Groen AK, Kunz W, Bohnensack R, Kster U, Letko G, Bhme G, Duszynski J, Wojtczak L
10.1038/s41591-024-03453-1 346 NusratS.GulickE.LevinthalD.BielefeldtK
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The adipose tissue triglyceride lipase ATGL/PNPLA2 is downregulated by insulin and TNF-alpha in 3T3-L1 adipocytes and is a target for transactivation by PPAR
Bedingfield, S
One potential mechanism is that increased circulating BCAA levels induce its cytosolic accumulation and constitutive activation of mammalian target of rapamycin complex 1 (mTORC1), inhibiting intracellular insulin signaling [67]
