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The affected peptides aren't permanently confined to Category 2

While not a substitute for targeted Lyme therapies, it may support immune stabilization during recovery

doi:10.1016/j.parkreldis.2023.105986

However, the use of RBD in vaccines is compromised by its limited immunogenicity owing to its small molecular size and possible mixed forms of multiple complexes (as monomers, dimers or trimers)