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For a detailed discussion of these mechanisms, please see several excellent reviews (Zarei et al., 2015

doi: 10.1038/srep08380 116 DornierERabasNMitchellLNovoDDhayadeSMarcoSet al

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As an acute viral infection, Ebola hemorrhagic fever (EHF) typically leads to a sudden onset of fever, weakness, and extreme muscle pain and headache