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doi: 10.1074/jbc.M705495200 40

There are multiple mechanisms that are involved in activating Nrf2, including interaction with cysteine residues on Keap1, disruption of Nrf2/Keap1 interaction, epigenetic modification and activation of protein kinases

Studies on breast cancer cell lines, including MCF-7 and MDA-MB-231, have demonstrated a significant increase in caspase activity and cell death following rhamnetin treatment, highlighting its role in apoptosis induction [89]

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