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In support of this, one study demonstrated that chronic morphine produced an increase in the number of active on-cells, likely increasing sensitivity to noxious stimuli (Meng and Harasawa, 2007), which may be responsible for morphine-induced hyperalgesia

10.1023/A:1008245400251 102 HilpertF.StahleA.TomeO.BurgesA.RossnerD.SpatheK.et al

Single-cell dissection of the human motor and prefrontal cortices in ALS and FTLD

Anti-and pro-oxidant effects of quercetin stabilized by microencapsulation on interstitial cells of Cajal, nitrergic neurons and M2-like macrophages in the jejunum of diabetic rats

Liao SY, Fingerlin T, Maier L

This could help patients with insulin resistance or diabetes by improving blood sugar regulation