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This innovative delivery system not only addresses the challenges associated with the difficulty of mRNA crossing cell membranes and its susceptibility to nuclease degradation in vivo but also plays a crucial role in ensuring the stability and efficacy of mRNA vaccines

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Consistent with what the authors observed in the human CNS, both EAE mice and CPZ mice showed intense upregulation of ATP7A, ATP7B, and CTR1 on astrocytes in the spinal cords in comparison to control mice (Colombo et al., 2021)