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Soy protein contains the hypo-cholesterolemic peptides IAVPTGVA, LPYP, and IAVPGEVA, which have been shown to influence cholesterol metabolism in HepG2 cells by inhibiting the pathway of a key enzyme (3-hydroxy-3-methylglutaryl coenzyme A reductase, HMG-CoA reductase) (Aiello et al., 2018)

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Schreiner AD, Moran WP, Zhang J, Livingston S, Marsden J, Mauldin PD, Koch D, Gebregziabher M (2022) The association of fibrosis-4 index scores with severe liver outcomes in primary care

doi: 10.1080/19490976.2020.1766936 8 AndermannM

10.1038/nrc1951 64 SidoliS.BhanuN

To dissect these regulatory pathways, we utilized a GluK3 (D759G) mutant, which ablates the LBD dimer interface zinc-binding site