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This initiates the production of C-terminal membrane-tethered -secretase-derived fragment C83, which, upon additional enzymatic cleavage by -secretase, increases the concentration of p3 [50]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 31.Martinez F.J., de Andrade J.A., Anstrom K.J., King T.E., Jr, Raghu G., Idiopathic Pulmonary Fibrosis Clinical Research Network Randomized trial of acetylcysteine in idiopathic pulmonary fibrosis

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