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Key aspects are highlighted as follows: (I) First-generation organic matrices: This category includes both traditional and novel SOMs, which are suitable for (+)MALDI-MS, (-)MALDI-MS, and (+/-)MALDI-MS analyses

In addition, multi-omics big data integration genomic, transcriptomic, proteomic, metabolomic enables deeper insights into human variability in supplement metabolism and therapy efficacy that may realize personalized supplement strategies depending on tumour subtype, host biology under their life style (254)

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In our experience, we have encountered histopathologically unequivocal benign nevi associated with acute inflammation in the form of abscess or folliculitis, which were classified as malignant by gene expression score (data not shown)

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