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doi:10.1056/NEJM198806303182604

Targeted inhibition of NNMT improves insulin responsiveness and may protect against diet-induced obesity. Hong et al., Nature Medicine Longevity and Anti-Aging Potential Because NAD is vital for DNA repair, circadian rhythm regulation, and mitochondrial health, 5-Amino-1MQ is being explored as a geroprotective agent especially when stacked with NAD boosters or sirtuin activators

Treatment with intramuscular injection of vitamin B12 was initiated (1000 mcg IM twice a week for a month, plus 100 mcg orally per day)

A study published in the Journal of Biological Chemistry demonstrated the effects of AMPK activation on glucose, fat cell metabolism and insulin resistance