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However, fertility studies in male animals were not performed

According to the American and European recommendations, metformin is considered a first-line oral hypo-glycemic drug for controlling type 2 DM (T2DM) patients

However, clinical trials focusing on the long-term safety and efficacy of polyphenols, particularly in combination therapies, remain a critical gap in the field
Differential activities of the ubiquitin-proteasome system in neurons versus glia may account for the preferential accumulation of misfolded proteins in neurons
In addition, proteomics data analysis was performed as mentioned in the method section labeled Proteomics analysis of sarcoma samples. The exact number of animals utilized for each experiment was mentioned in the figure legends of primary and Supplementary Figures

Furthermore, another study showed that serum IGF-1 levels, but not PSA levels, tended to be lower in patients with higher surgical Gleason scores
