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Figure 2 - Scheme of the chemical biotransformation process (Phases I, II and III).Source: Although not a portal of entry, the kidney is an organ where xenobiotics are likely to be concentrated during the excretion process and this may explain the high level of xenobiotic-metabolizing enzymes in this tissue

10.1155/2014/151479 [DOI] [PMC free article] [PubMed] [Google Scholar] Pickart L., Vasquez-Soltero J

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[52] Phenylketonuria may contraindicate the use of certain ondansetron formulations that contain aspartame or other phenylalanine-containing excipients