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Lysosomal proteases, like other secretory pathway proteins, are co-translationally translocated across the ER membrane and mature in steps through the ER and Golgi

Use aseptic technique for multiple withdrawals

In patients with cirrhosis, aldosterone-induced signaling pathways can exacerbate hepatic fibrosis by stimulating hepatic stellate cells and increasing extracellular matrix deposition
Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents

doi: 10.1210/er.2013-1058 20 SagoeDTorsheimTMoldeHAndreassenCSPallesenS

Griffiths HBS, Williams C, King SJ, Allison SJ