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194, 195 Whether this constitutes an off-target mechanism of resistance or rather reflects the inhibition of caspase-9 by AKT1-transduced signals 196 (hence representing a post-target effect) remains to be clarified

MGO is actually a precursor for 1-acetyl-6, 7- dihydroxyl-1, 2, 3, 4-tetrahydroisoquinoline (ADTIQ), a dopamine (DA)-derived tetrahydroisoquinoline (TIQ) toxin that is also found in PD brain tissue [339]