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Doses greatly exceeding the nutritional requirements (for example, hundreds of milligrams daily) have not been studied in randomized trials for safety, so one should avoid mega doses in pregnancy unless treating a specific condition (such as pyridoxine-responsive seizures) under careful supervision

Trauma 139 McKeeA.GavettB.SternR.NowinskiC.CantuR.KowallN.et al (2010)

Injectable b12 bypasses all absorption issues, providing 100 percent bioavailability regardless of stomach acid levels or intrinsic factor status

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Lean poultry and fish digest more easily than red meat during the initial treatment period

It is formed by endothelial cells connected through tight and adherens junctions, supported by pericytes and astrocytic end-feet comprising the neurovascular unit