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In addition, Nrf2 induces the expression of SLC7A11, which promotes cystine uptake and supports GSH production, thereby reinforcing the cellular defense against ferroptosis (49)

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5H, I), while overexpression of a codon-optimized L2HGDH (L2HGDH OPT ), which is resistant to the designed sgRNA, reverses this effect (Fig

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NiemannPick Disease NPC, type C1 (NPC1) is a lysosomal disorder linked to mutations in the NPC1 gene, leading to the abnormal trafficking and accumulation of lipids, primarily cholesterol, in brain cells