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Though ALC may delay the onset of some behavioral deficits, it does not significantly improve performance on behavioral tasks assessed later in life, for example locomotor activity (PN 42), rotorod (PN 44) or associative fear conditioning (PN 45)

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Instead of being burned for fuel, these fats accumulate outside the mitochondria, leading to lipotoxicity and further cellular stress

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The blockade of ERK1/2 activation by U0126 (a MAPK kinases inhibitor) attenuated the IRE1 level, suggesting that ERK1/2 activation causes ER stress activation in PFOS-treated RTCs (Fig

Resistance training and adequate protein intake can help preserve muscle mass and support metabolic health more effectively than pharmaceutical interventions alone