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First, be aware of what depletes glutathione

The standard protocol is 10 units (4mg total blend) at 5x/week during loading

doi: 10.1186/s12974-018-1373-4 105 KradyJ

2017;6(6):p

The observation that patients with AD carrying two alleles of the APOE4 risk variant have approximately half the cerebrospinal fluid (CSF) melatonin levels compared to those with only one allele of this variant [75] could suggests that APOE4/4 carriers might particularly benefit from supplementing with exogenous melatonin

Why it matters: A potent, natural antioxidant
