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This meta-analysis has several limitations

Full text: DePhillipo, N

However, there have been a few studies that have reported a link between chronic oral ingestion of high doses and the body's intestinal microbiota metabolism, leading to increased TMAO (a compound linked to cardiovascular risk) [7]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 259.Kano M., Nishibe T., Dardik A., Iwahashi T., Ogino H

Cardiovascular and autonomic responses to energy drinks-clinical implications