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Comm 6:123-138, 2001

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An increase in the activity of matrix-metalloproteases (MMPs) or an increase in neuronal glucose uptake are two likely mechanisms by which inhibition of IRAP can provide an enhancement of memory

Additionally, it regulates the MAPK signaling pathway by inhibiting the phosphorylation of ERK, JNK, and p38, further reducing ROS production 200

Early results from the REDEFINE-4 trial showed that participants lost an average of 22.7% of their body weight, making it a potential competitor to existing treatments

The study included 3 phases: screening and baseline assessment (614 days), randomization (1 day), and treatment (12 weeks) (see Supplementary Fig