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To achieve maximum efficacy from the antioxidants in vivo, their bioaccessibility and bioavailability must be increased by using appropriate delivery systems, such as liposomes, nanoparticles, etc

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In another six-month, randomized, double-blind, placebo-controlled study of subjects with mild-to-moderate AD, curcumin failed to improve cognitive test scores and to reduce blood and cerebrospinal fluid (CSF) concentrations of -amyloid peptide, CSF concentrations of total and phosphorylated Tau protein, and CSF concentrations of F 2 -isoprostanes (98)