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have evidenced an initial GSH increase, followed by a progressive depletion [99]

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doi:10.1007/s00134-018-5118-8 84 Sriperumbuduri S, Clark E, Biyani M, Ruzicka M

The N-terminal domain consisting of 80-odd residues adopts a thioredoxin-like fold and harbors the G-site, which binds glutathione with a number of highly conserved residues as well as with ionic bonds from Asp101 and Glu 131 in the adjacent subunit (Figure 4)