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Molecular mechanism and function of CD40/CD40L engagement in the immune system

Exclusion criteria included non-rodent species, animal models centered on general neurological or psychiatric conditions not specific to ASD, and non-pharmacological or non-gut microbiota interventions (behavioral, dietary, device, surgical, herbal only)

We then summarize reported cases of patients with biallelic pathogenic variants in Mn transporter genes, detailing their phenotypes and therapeutic interventions, as well as relatively common diseases linked to an Mn imbalance

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Highly lipophilic compounds have an increased risk of being poorly soluble, quickly metabolized and promiscuous binders, whereas more polar compounds often are less permeable