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These findings confirm that the absence of dose-response is robust to landmark conditioning

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Administering 75 mg/kg/day of FA to high-fat-fed LDL receptor-deficient (LDLR/) mice for 16 weeks resulted in a significant inhibition in atherosclerosis plaque progression and vascular smooth muscle cell (VSMC) dedifferentiation by modulating the mTOR/p70S6K signaling pathway, which involved the reduction in lipid levels and the suppression of oxidative stress and inflammatory response [82]

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Even though there has been a lot of progress in nanomedicine, the translation of NP-based therapies into clinical practice remains hindered by challenges related to their size, stability, and biodistribution

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10.1111/j.1440-1681.2010.05383.x 240 RizzaS.MuniyappaR.IantornoM.KimJ.ChenH.PullikotilP.et al (2011)

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As the SnCE1 tetramer formation is structurally incompatible with SUMO1 binding at S1, we hypothesize Lys231-acetylation of SnCE1 promoting its deSUMOylase activity by stabilization of the SnCE1 monomeric state (Fig

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Arch Gerontol Geriatr 34:371377

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