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It appears, that only a small fraction of the catechol estrogens in the COC users were converted into estrogen-DNA adducts or glutathione conjugates, since the overall abundance of these were either decreased or were unaffected (Tables 1 and 2

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This modification process regulates the structure and function of proteins, usually by making them more compact or affecting their stability and activity within the cell [59]

Animal models of oral carcinogenesis confirm these mechanisms, where antifungal therapy reduces squamous hyperplasia and carcinoma incidence, directly linking C

10.3945/jn.109.108316