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The crude extract is subsequently redissolved and purified through various chromatographic techniques, including ion exchange and gel filtration chromatography

Regulation of VWF (Von Willebrand Factor) in inflammatory thrombosis
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doi: 10.1111/j.1365-2125.2005.02523.x

The calcineurin inhibitor FK506 (tacrolimus) is associated with transient metabolic acidosis and altered expression of renal acid-base transport proteins
