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Lee JW, Choi E, Son JW, et al


Curcumin has protective properties on liver and kidney functions at different doses and showed efficacy in lowering liver enzymes and bilirubin

114: 1-10 (2021) Roberfroid M, Bornet F, Bouley Ce, Cummings J

However, its clinical application has been limited by dose-dependent gastrointestinal toxicity observed in later phase I and II clinical trials
During acute inflammation, pro-inflammatory M1-like macrophages accumulate in the liver, characterized by elevated expression of the NAD +degrading enzyme CD38 and increased CD38-dependent NADase activity, leading to reduced tissue NAD + levels (Stahl et al
