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In contrast to this, the GSSG form concentration decreased during infections caused by, for example, PVY NTN and TuMV (Otulak-Kozie et al., 2022a, b)

Irinotecan can be activated by carboxylesterase 1/2 (CES1/2) and catalyzed to a more active metabolite SN-38, both of which could form an inhibitory complex with TOP1 and DNA (Takano and Sugiyama, 2017)

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Epidemiological studies have shown associations (though not necessarily causation) between higher circulating IGF-1 levels and increased risk of certain cancers including prostate, breast, and colorectal cancers
