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showed that cholesterol crystals serve as DAMPs and cause the activation of the NLRP3 [nucleotide-binding domain leucine-rich repeat containing (NLR) family, pyrin domain containing 3] inflammasome in macrophages (Rajamaki et al., 2010)

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Lippincott, Williams & Wilkins, 2013

While the curcumin dosage may still require further research, its effect in alleviating airway constriction and increasing forced expiratory volume in one second and forced expiratory volume in one second/forced vital capacity values has been widely accepted as significant

Based on the oxidative stress hypothesis, oxidative damage is not solely triggered by the unrestricted ROS production, but it also caused by other oxidants, such as reactive lipid species and reactive nitrogen species (RNS)