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Cellular antioxidant resources, such as GSH, are exhausted, accelerating the progression of ferroptosis [135]

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Notably, M1 macrophages are more resistant to ferroptosis than M2 macrophages, largely because of elevated levels of inducible nitric oxide synthase (iNOS) (Kapralov 2020)

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The roles of ros in cancer heterogeneity and therapy

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Moreover, lipophagythe selective degradation of lipid dropletsplays a significant role in these processes

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The importance of GSH in cancer treatment is best illustrated by the fact that BSO, the irreversible inhibitor of GCL, is now often used as an adjuvant chemotherapeutic agent to sensitize tumor cells to the effects of chemotherapy (Reber et al., 1998

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Maintenance is physiologically easier than reconstruction

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