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In support of alternative hypotheses, cuprizone induced significant intraneuronal amyloid deposition in young APP/PS1, but not in R1.40 mice, and it suggested the presence of PSEN deficiencies, may accelerate A deposition upon demyelination

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However, control of the mechanism of GSH synthesis in malignant tumors remains poorly understood

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Goal: Maintain stability preventing progression while balancing cost and intervention burden