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KEGG pathway enrichment analysis of the RA-FMS comorbidity targets identified 67 signaling pathways, including 35 non-disease-related pathways after exclusion

[58] A June 2025 study suggests that the difference may be attributable to the AS01 adjuvant used in Shingrix as the AS01-containing RSV vaccine (Arexvy) shows a very similar reduction in dementia risks

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