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Role of S-adenosyl-L-methionine in the treatment of intrahepatic cholestasis

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CNS Effects Sedative effects have occurred in patients receiving valproate alone but occur most often in patients receiving combination therapy

There is one consideration worth discussing openly: theoretically, L-carnitine may affect thyroid function

Future work should prioritize clinical validation of TMAO-lowering interventions and elucidate tissue-specific mechanisms underlying its dual roles in inflammation resolution and exacerbation
