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[3] The most conserved region in all these proteins is centred on a serine residue which has been shown [4] to participate, with a histidine and an aspartic acid residue, in a charge relay system

S467 (TM11) in turn makes an interhelical hydrogen bond with S157 (TM2) and forms an interaction network linking the N- and C- terminal bundles (Fig

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Characterization and Separation of the Arachidonic Acid 5-Lipoxygenase and Linoleic Acid Omega-6 Lipoxygenase (Arachidonic Acid 15-Lipoxygenase) of Human Polymorphonuclear Leukocytes