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To be absorbed, the vitamin needs to be attached to a protein called intrinsic factor

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Excessive copper levels in the liver have been demonstrated to result in a number of physiological consequences, including mitochondrial dysfunction, the downregulation of copper influx, the upregulation of metallothioneins (MTs), and ultimately, cell death

Cognitive impairments accompanying rodent mild traumatic brain injury involve p53-dependent neuronal cell death and are ameliorated by the tetrahydrobenzothiazole PFT-