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Due to dose-dependent hepatotoxicity and nephrotoxicity, MTXs clinical usage is restricted
Fine motor dysfunction, dysarthria, and dysphagia may occur when subcortical motor pathways and brainstem structures are involved

Conclusions The evolving nature of our understanding of cysteine and homocysteine in pathological processes reflects the dynamic and interdisciplinary nature of scientific research

doi: 10.1038/tp.2011.37 151 AkiraSTakedaK

Roshanzadeh G, Jahanian Sadatmahalleh S, Moini A, Mottaghi A, Rostami F

Gu M, Zhou X, Sohn JH, Zhu L, Jie Z, Yang JY, et al