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A polyubiquitin chain attached to lysine residue labels the proteins intended for ATP-dependent proteolysis in proteasomes and stimulates various downstream signals involved, such as apoptosis, cell cycle control, NF-B activation, and DNA repair [58]

10.1097/01.pgp.0000152024.37482.63 [DOI] [PubMed] [Google Scholar] 77

Int J Cancer (2016) 139(11):252939.10.1002/ijc.30371 32 BjersandKSeidalTSundstrom-PoromaaIAkerudHSkirnisdottirI

However, the delivery system's surface may have a neutral or negative charge, which helps to minimize cytotoxicity

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In a rat model of Alzheimers disease induced by amyloid , luteolin combined with L-theanine can inhibit TNF-, reduce neuroinflammation, and improve memory function [41]
