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Prevention Use lip sunscreen or protective balms to prevent sun-triggered irritation and burns [Mayo Clinic] Avoid known allergens or irritating lip products Reduce habits like lip biting Practice good hygiene to prevent viral spread If cold sores recur due to triggers such as stress or illness , discuss preventive strategies with a clinician [CDC] When to See a Doctor Seek medical evaluation if: The blister lasts longer than two weeks You develop fever with the blister [CDC] Redness spreads, pus develops, or infection is suspected The blister is extremely painful or interferes with eating Blisters recur frequently You experience eye irritation during a cold sore outbreak (possible HSV eye involvement) [CDC] Frequently Asked Questions Is every blister on the lip a cold sore