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To define whether paclitaxel induces the activation or the inhibition of C5aR1 through its binding, we then performed a cell-based cAMP assay in single dose experiments and found that paclitaxel can activate, but not inhibit, C5aR1, while dose-response experiments showed that paclitaxel EC 50 is 5.81 M and Emax around 50%, demonstrating that paclitaxel is a new partial agonist of C5aR1 (Fig

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We hope to provide a solid theoretical basis and a clear research framework for understanding the core role of exosomes in SCI repair and promoting their clinical translation and application through this review,

A phase 2 study of bortezomib in relapsed, refractory myeloma

Immunohorizons 6 , 476487 (2022)

Mice were group-housed and maintained at room temperature (2325 C) on a standard chow diet with a 12-h lightdark cycle and free access to water and food unless specified