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doi: 10.1007/s40265-018-0942-2 135 KrishnanSMDowlingJKLingYHDiepHChanCTFerensDet al
Rerely hypersensitivity reactions like rash may occur

Renal D-amino acid oxidase, an enzyme found in kidney tubules, is the only known mammalian enzyme that can use the D(KLAKLAK)2 moiety as a substrate

Over the decades, the FDA has regulated these kinds of substances as drugs, and their manufacturers have had to prove that the products are both safe and effective before putting them on the market
Critically, HDM-2 is not expressed on the outer cell membranes of normal, untransformed cells making PNC-27s mechanism inherently selective for cancer cells in laboratory models

Rubery PT, Bukata SV