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However, under certain conditions, such as chronic tubulointerstitial injury with pre-existing loss of the peritubular microvasculature, the unilateral enhancement of mitochondrial biogenesis could exacerbate the existing pathological conditions (Weinberg, 2011)

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It could mean the difference between long-term sobriety and relapse

Speilberg, S
Moreover, Kyn pathway may critically influence glutamate neurotransmission [225]
