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60,61 CAUSES OF NAD+ DECLINE The above discussion demonstrates clear evidence for the role of NAD+ decline in the development of the hallmarks of aging in the skin, and there has been great interest in understanding the root causes of NAD+ decline to determine strategies to successfully restore cellular NAD+ levels

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A small human study on chronic pain patients showed significant reductions in pain levels for 6 out of 7 subjects after DSIP treatment

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In CFS, the fatigue tends to be overwhelming, and is not relieved by sleep or rest