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Parkin-assembled ubiquitin chains can also recruit autophagy adaptors in complexes with a multifunctional protein kinase complex called TANK-binding kinase 1 (TBK1), which directly phosphorylates Ras-associated protein 7A (RAB7A) and promotes mitophagy through the PINK1/Parkin pathway [63]

In rare cases, sickle-cell crisis has occurred in patients with sickle cell disease because of decreased blood pH (6)