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The newly recruited monocytes express a pro-inflammatory phenotype (Ly6C hi ) [103] and there is evidence that during the very early phase of their recruitment (812 h after APAP) these cells can cause a temporary mild aggravation of the injury [108]

It plays a crucial role in various physiological processes such as development, immunity and energy metabolism, and its dysregulation has been found in numerous diseases such as cancer, neurodegenerative disorders and metabolic syndromes

Deng L, Liang H, Xu M, Yang X, Burnette B, Arina A, Li XD, Mauceri H, Beckett M, Darga T, et al

Gender differences control the susceptibility to ER stress-induced acute kidney injury

Both promote healing but through fundamentally different mechanisms

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