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Premature aging is associated with higher levels of 8-oxoguanine and increased DNA damage in the Polg mutator mouse

In the words of Jeremy Appleton, ND, chairman of the department of nutrition at the National College of Naturopathic Medicine in Portland, Oregon: If you look in a hospital situation at people who have cancer, AIDS, or other very serious disease, almost invariably they are depleted in glutathione

Further, the amyloid precursor protein has copper-binding domains allowing it to function as a copper chaperone in the brain

One study noted that B12 supplements, along with folic acid, improved symptoms of neuropathy in patients treated with certain chemotherapy agents
