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Retatrutide is an investigational drug not yet approved by the FDA
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It has been reported that caspase-9 and caspase-3 expression was elevated in both HEI-OC1 cells and cochlear exposed to aminoglycosides, and the use of caspase-9 specific inhibitor (z-LEHD-FMK) or general caspase inhibitor (z-VAD-FMK) was found to effectively reduce the expression of caspase and prevent HC death (Matsui et al., 2003
Holekamp, Biochemical mechanisms of age-related cataract, in Ocular Disease, A.L
