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Low molecular weight complexes contained IGF-I or IGF-II bound to an insulin regulated liver derived protein IGFBP-1 (17, 18), at first called the 28 kDa binding protein or PP12 (19)

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4 Musculoskeletal disability In our cohort we observed significant variability in the severity of musculoskeletal symptoms and their effect on day-to-day function between the different probands and even within the same family