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No, of course not

Diamine oxidase (DAO) activity, d-xylose, histamine and citrulline concentrations in the plasma D-xylose and diamine oxidase (DAO) in plasma were determined by using commercially available kits (Jiancheng Institute of Biological Technology, Nanjing, China)

All animal procedures were approved by Institutional Animal Care and Use of Chongqing Medical University (IACUC-CQMU-2024-0266)

doi: 10.1080/09540105.2021.2022604 35 IkonenE

The extract inhibited tyrosinase activity (IC50 = 0.713 mg/mL) and reduced melanin production (IC50 = 0.711 mg/mL) in the melanin-producing B16F10 mouse melanoma cell line

For good bioavailability of drugs in the brain, the formulations physical-chemical characteristics must be optimized for this route of transport and to avoid the physiological clearance mechanisms of the nasal cavity