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The tradeoff is stark underperformance during growth-driven markets

Life Sci 241:117148 Dombi E, Mortiboys H, Poulton J (2018) Modulating mitophagy in mitochondrial disease

A peptide with reduced acidity was designed for increased cell permeability The p53 TAD2 sequence exhibited a highly negative charge, whereas the p53 binding interface of the FOXO4 FHD contains several positively charged residues

A key challenge arises from the cysteine residue, which is prone to heterogeneous post-translational modifications of the thiol group that result in multiple unknown isoforms, effectively diluting an already low-density target 17
Hydration and gradual dose escalation may minimize this concern
Safety and efficacy of ARA 290 in sarcoidosis patients with symptoms of small fiber neuropathy: a randomized, double-blind pilot study. Molecular Medicine, 18, 14301436
