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A randomized phase III clinical trial involving 600 early PD patients found no evidence of clinical benefit with high-dose CoQ 10 (1200 mg/d and 2400 mg/d) supplementation (207)

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Overexpression of Nur77 activates mitochondrial autophagy, reduces apoptosis, and regulates follicular number and hormonal abnormalities caused by ovarian aging, ultimately improving ovarian function [98]

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